Plasma Industries - CAF

Plasma Industries in collaboration with CRC Engineering

A cGMP cleanroom environment 

Plasma Industries is a company founded in 1957 by the Belgian Red Cross.
In the production unit in Neder-Over heembeek the fractionation of 500.000 liters/year of blood plasma takes place. Using high-tech and innovative processes, they isolate valuable proteins from the plasma.
Plasma Industries takes care of the preparation of cryo-paste, fraction II, fraction V and DS-Eluates. These fractions are the basis for producing drugs that help patients with blood clotting problems, a lowered immune system, an insufficient blood volume or who suffer from hereditary angioedema. This process takes place in a cleanroom environment in order to guarantee the quality of the pharmaceutical products imposed by the European and American cGMP guidelines. 
CRC engineering assisted the client to realize this.

The building provides for following functions
  • Production
  • Storage
  • Offices
  • Technical rooms

The production process consists of
  • Fractionation
  • Separation
  • Chromatography
  • Ultra-filtration


Services provided

  • Pre-design
  • Detailed Design
  • Project Management
  • Construction Management
  • Commissioning


Applied Techniques

General Techniques
  • Ventilation
  • Cooling
  • Heating
  • Electricity
  • Data 
  • Fire detection
  • Compressed Air
  • Gas distribution
  • DI Water
  • City water
  • Vacuum
Cleanroom design
  • Class C
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